Mean PCC increased for 10 of 11 test GSC datasets when H3K27Ac is the only feature.

The percent change values for the Mack et al. datasets, each split into 10 non-overlapping sections, aligns with those from the other testing strategy (Table 1) [25]. GSC2 is the only dataset whose performance decreased when testing with H3K27Ac only. This supports the notion that the H3K27Ac signal alone is sufficient for strong gene expression prediction using this study’s experimental setup. (XLSX)