Allelic association of two common POMC variants and BMI.

rs10654394: a 9-bp insertion/deletion polymorphism (−/AGCAGCGGC) in POMC exon 4; rs1042571: C/T in POMC 3′UTR.AAs: African Americans; EAs: European Americans.Normal weight: BMI = 18.5–24.9; Overweight: BMI = 25–29.9; Obese: BMI ≥30.Pobs: observed P values calculated by Chi-square tests; Pemp: empirical P values using 10,000 permutations; Padj: P values obtained from multivariate logistic regression analysis and adjusted by sex, age, substance dependence (SD) status, and ancestry proportion.Allele freq*: numbers before the slash symbol “/” represent the allele frequency in the conditioned group (i.e., overweight, obese, or over weight + obese groups), and numbers after the slash symbol “/” represent the allele frequency in the comparison group (i.e., the normal weight group).