Statistical significance (p-values) of topological characteristics in real networks tested against randomly rewired samples.

*Properties which can differ between the original network and the random samples of rewired networks, respectively, have been tested for significance by calculating the p-value from a normal distribution using the z-score. The original path sum has been compared to the path sums of random counterparts being in the same index class as the original network.The p-value for the structural robustness in the Transpath kinase network is extremely low, the corresponding p-value for the neighborhood index, , is .