Overexpression of FOXO1 enhances CAR T cell polyfunctionality, metabolic fitness and efficacy against solid tumors [Human ATACseq CD8]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE225521
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Investigating the effect on CAR T cell phenotype by overexpressing FOXO1 Human PBMCs were transduced to express a human Lewis-Y directed CAR and FOXO1 or mCherry. Following transduction, CD8+ CAR T cells were sorted and analyzed by ATAC-seq
创建时间:
2024-05-08



