Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast.
收藏PubMed Central1993-11-15 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC47801/
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资源简介：
In a screen designed to isolate human cDNAs that complement a yeast G2 phase checkpoint mutation (mec1), we isolated a cDNA homologous to the Saccharomyces cerevisiae CDC34 gene. The human CDC34 cDNA can functionally substitute for the yeast CDC34 gene and represents a mammalian homolog of the group of yeast genes required for the late G1-->S phase transition. The human CDC34 gene is expressed in multiple cell lines as a unique species and Southern blot analysis reveals evidence for a single gene that is highly conserved in higher eukaryotes. The human gene is located on the far telomeric region of 19p13.3 in a location that defines a region of homology between human chromosome 19p and mouse chromosome 11. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1993-11-15
