H3K36 methyltransferase NSD1 is essential for normal B1 and B2 cell development and germinal center formation. H3K36 methyltransferase NSD1 is essential for normal B1 and B2 cell development and germinal center formation

This study aims to illustrate the effect of H3K36 methyltransferase NSD1 in B2 cells. Overall design: Comparative gene expression profiling analysis of RNA-seq data for WT B220+ B cells (Mb1-Cre+ NSD1+/+) and its NSD1 conditional knockout derivatives (Mb1-Cre+ NSD1fl/fl).