Identification of immunogenic double-stranded RNAs in human cell lines
收藏NIAID Data Ecosystem2026-05-02 收录
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We expressed different isoforms of ADAR proteins in human cells without A-to-I RNA editing activity to test which isoform(s) was able to rescue the interferon induction phenotypes caused by activation of MDA5 in the absense of double-stranded RNA editing. Using the rescue cells, we sequenced the RNA and profiled RNA editing in order to identify the key RNA editing substrates for MDA5 sensing. Total RNA profiles of wild type (WT) and mutant HEK293 cells expressing different ADAR isoforms/proteins were generated by deep sequencing
创建时间：
2025-09-01
