Application of iGUIDE to identify potential off-target cleavage caused by Cas9/PD1 sgRNA
收藏NIAID Data Ecosystem2026-03-13 收录
下载链接：
https://www.ncbi.nlm.nih.gov/bioproject/PRJNA772894
下载链接
链接失效反馈官方服务：
资源简介：
We successfully develop a two-in-one approach to generate non-viral genome specific targeted CAR T cells through CRISPRCas9. In the adoptive therapy for relapsedrefractory aggressive B-cell non-Hodgkin lymphoma, we observed durable responses without serious adverse events and complete remission in patients treated with these PD1 knockout CAR T cells. Here we applied iGUIDE to identify potential off-target cleavage caused by Cas9/PD1 sgRNA.
创建时间：
2021-10-20
