Genome-wide RNA-seq from PARP1 and PRC2 double-depleted MDA-MB-231 cell lines
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https://www.ncbi.nlm.nih.gov/sra/SRP239117
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Purpose: To identify downstream signaling pathways mediated by PARP1 and PRC2 in breast cancer Methods: RNAs isolated from MDA-MB-231 cells depleting PARP1 and EZH2 (PARP1 KO shEZH2) and PARP1 and SUZ12 (PARP1 KO shSUZ12) were analyzed by using an Illumina Nextseq500 Conclusions: Our study represents the first transcriptomic profiles of effects of PARP1 and PRC2 double deficiency in breast cancer Overall design: mRNAs prepared from wild type, PARP1-EZH2 double-depleted and PARP1-SUZ12 double-depleted MDA-MB-231 cells were analyzed in duplicaters by Illumina Nextseq500.
创建时间：
2021-01-03
