ERGIC-to-Golgi vesicles bind dynein:dynactin

Unlike COPII-mediated traffic from the ER, COPI traffic to the Golgi is microtubule- and dynein-dependent (Scales et al, 1997; Presley et al, 1997; Ben-Tekaya et al, 2005). Recruitment of the dynein:dynactin complex may in turn rely on interaction with the ankyrin-spectrin network, which may contact integral membrane cargo proteins as they are incorporated into nascent COPI vesicles (Devarajan et al, 1997; Godi et al, 1998; Holleran et al, 1996; Holleran et al, 2001). Although not depicted in this reaction, dynein-dependent vesicle transport is energy dependent.

与COPII介导的内质网交通不同，COPI向高尔基体的交通依赖于微管和动力蛋白（Scales等，1997；Presley等，1997；Ben-Tekaya等，2005）。动力蛋白:动力蛋白复合物的募集可能进而依赖于与ankyrin-spectrin网络的相互作用，该网络可能在与新生的COPI囊泡结合时接触整合膜货物蛋白（Devarajan等，1997；Godi等，1998；Holleran等，1996；Holleran等，2001）。尽管本反应图中未展示，动力蛋白依赖的囊泡运输是能量依赖性的。