Cleavage of collagen VII NC2 region by BMP1

Bone morphogenetic protein-1 (BMP1) cleaves the C-terminal propeptide from human procollagen VII within the NC2 domain at the BMP1 consensus cleavage site SYAA|DTAG. Mammalian tolloid-like (mTLL)-1 and -2 can substitute for BMP1 (Ratttenholl et al. 2002).

骨形态发生蛋白-1（BMP1）在BMP1的共识切割位点SYAA|DTAG处，于NC2结构域内切割人原胶原蛋白VII的C端前肽。哺乳动物的类tolloid蛋白（mTLL）-1和-2可以替代BMP1（Ratttenholl等，2002年）。