Hepatic T-cell senescence is implicated in the progression of fatty liver disease in patients with type 2 diabetes

Immunosenescence and exhaustion are involved in the development and progression of type 2 diabetes (T2D) and metabolic liver diseases, including fatty liver, fibrosis, and cirrhosis, in humans. However, the relationships of the senescence and exhaustion of T cells with insulin resistance-associated liver diseases remain incompletely understood. To better define the relationship of T2D with nonalcoholic fatty liver disease, 59 patients with T2D were studied. Metabolic liver disease mice made by feeding the High Fat High Fructose diet (HFrD) for 24 weeks. The liver immune cells were isolated by Percoll gradient method and analyzed using scRNAseq