CpG dinucleotides introduced into gag can inhibit HIV-1 gene expression by modulating pre-mRNA splicing
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https://www.ncbi.nlm.nih.gov/sra/SRP214310
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资源简介：
Progressively longer regions of the gag gene sequence in HIV-1 were codon-optimized, which introduced 11, 18 or 26 CpGs (CM22-165: codon-optimized gag from nucleotide 22 to 165, adding 11 CpGs; CM22-261: 18 CpGs; CM22-378: 26 CpGs). Overall design: Two independent transfections of HeLa cells with plasmids encoding HIV-1 provirus were performed for each of the codon-optimized HIV-1 versions as well as the un-optimized, wildtype version of HIV-1.
创建时间：
2020-04-28
