SPIKES: Identification of physicochemical properties of spike proteins across diverse host species of SARS-CoV-2. Yerukala Sathipati et al.

To determine the significance of compositional changes in amino acids in S proteins from different strains of CoVs, we compared changes between Rousettus bat coronavirus (GenBank: AOG30822.1) and hCoV/wuhan/WIV05/2019 strain using the hCoV-19 spike glycoprotein mutation surveillance dashboard, GISAID. We used GISAID data statistics to examine the amino acid changes in the S protein that increased the infectivity in emerging new variants.