Post-resolution macrophage-derived lipids shapes long-term tissue immunity and integrity
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Supplementary Figure 1. Gating strategy to identify T cells population in the inflamed and resolving mouse lung following inoculation with S. pneumoniae.
Supplementary Figure 2. Profiles of T cells populations and their intracellular effector molecules in the inflamed and resolving mouse lung following inoculation with S. pneumoniae.
Supplementary Figure 3. Strategy for depleting circulation monocytes in a therapeutic manner in resolving mouse lung following inoculation with S. pneumoniae and the impact of this intervention on blood monocyte populations.
Supplementary Figure 4. Following from Figure 5 In the manuscript, these data are a comprehensive profile of other lipid mediators (prostanoids, hydroxy- and epoxy-fatty acids) in the naïve, inflamed, resolving and post-resolution lung following inoculation with S. pneumoniae as measured by LC-MS/MS.
Supplementary Figure 5. Expression of (A-B) COX-2, mPGES-1 at protein level in immune cells at onset and (C-D) post-resolution phases as well as (E-F) EP4 post-resolution macrophages and CD3-positive T.
Supplementary Figure 6. Levels of PGE2 following depletion of lung macrophages using MC-21.
Supplementary Figure 7. Development and resolution of tissue fibrosis in S. pneumoniae induced transient lung inflammation.
Supplementary Figure 8. Effects of therapeutically depleting post-resolution macrophages with MC-21 on lung fibrosis.
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figshare
创建时间：
2023-10-16
