Sex differences in susceptibility to influenza A virus infection depend on host genotype

Using influenza A virus (IAV) infection in a mouse model of  naturally selected genetic diversity, namely C57BL6/J (B6) mice carrying chromosomes (Chr) derived from the wild-derived and genetically divergent PWD/PhJ (PWD) mouse strain (B6.ChrPWD consomic mice), we examined the effects of genotype and sex on severity of IAV-induced disease To determine the role of genetic variation of host during IAV infection on gene expression, we performed RNAseq analysis on whole lung RNA isolated from two different mice. Comparative gene expression profiling analysis of RNA-seq data for male and female B6 and B6.ChrX.3PWD mice on on day 6 post-infection with IAV Please note that each processed file contains mouse genotype comparison within each sex with the normalized count values for all samples (instead of only 8 samples that were being compared).