Expression data from tumors generated from genome-engineered mice
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE75435
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Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations are found in 30–40% of human colorectal cancers (CRC). However, specific therapeutics against KRAS-mutated CRC have not been established. We have previously reported mouse models for colon cancer with and without Kras mutations (CDX2P-G22Cre;Apcflox/flox; KrasG12D and CDX2P-G22Cre;Apcflox/flox mice, respectively). Herein, we aimed to identify candidate genes as novel therapeutic targets or biomarkers for KRAS-mutated CRC by comparing the gene expression profiles of these two mouse models. At an age of 6–8 weeks, 3 tumours were harvested from each of the two mouse models and gene expression profiles were generated using microarrays (GeneChip Mouse Genome 430 2.0 Array; Affymetrix, Santa Clara, CA)
创建时间：
2019-02-11
