RNA-seq reveals distinct renal responses to murine trypanosomosis in susceptible and tolerant mice

To understand broad mechanisms that underlie differential susceptibilities to murine trypanosomiasis, we infected BALB/c and C57BL/6 mice with Trypanosoma brucei We obtained kidneys from infected mice at early (day 7) and late (day 21) infection time points and performed bulk RNA seq on the kidney lysates using poly-A enrichment Comparative transcriptomic analysis of RNA-seq data for the kidney of Trypanosoma brucei infected mice with differential susceptibilities at early and late infection time points BALB/c: susceptible C57BL/6: resistant