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Structure-Based Organic Synthesis of a Tricyclic <i>N</i>-Malayamycin Analogue

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NIAID Data Ecosystem2026-03-06 收录
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The solid-state structure of crystalline malayamycin A reveals a urea substituent that bisects the plane of the chairlike tetrahydropyran subunit. On the basis of this topological feature, we synthesized a tricyclic N-nucleoside analogue in which an ethano bridge linked the urea NH group with the ring junction of the bicyclic tetrahydrofuropyran unit.

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2016-02-29
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