Design and synthesis of potent hydroxyethylamine (hea) bace-1 inhibitors
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Design and synthesis of potent hydroxyethylamine (hea) bace-1 inhibitors Descriptor: Beta-secretase 1, N-[(2S,3R)-4-{[(4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-thieno[2,3-b]pyran-4-yl]amino}-3-hydroxy-1-phenylbutan-2-yl]acetamide Authors: Borkakoti, N, Lindberg, J, Derbyshire, D. Deposit date: 2012-04-30 Release date: 2012-10-31 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Design and synthesis of potent hydroxyethylamine (HEA) BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates. Bioorg.Med.Chem.Lett., 22, 2012
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2012-04-30
