The metabolic costs of meiotic drive

Selfish genetic elements, such as meiotic drive genes, disrupt Mendel’s law of equal segregation by biasing their own transmission, often at a detriment to the rest of the genome. Metabolic costs of the X-linked sex-ratio (SR) meiotic drive were investigated in stalk-eyed flies (Teleopsis dalmanni). The experiments demonstrate that individuals with SR have reduced capacity for ATP synthesis. The disruption in mitochondrial function leads to compensation exhibited in increased basal metabolic rate and greater food consumption across a range of diets. The range of metabolic costs of drive was evident in males and females at a similar magnitude. The likely cause lies in the accumulation of deleterious mutations within the series of large inversions on the drive X chromosome, subject to low recombination and weak natural selection. In females, the drive chromosome had a dominant effect, with a single copy causing substantial metabolic compromise. There was little evidence of male-specific m..., , # The metabolic costs of meiotic drive

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Principal Investigator Contact Information
Name: Andrew Pomiankowski
Institution: UCL
Email: [[e-mail]](mailto:[e-mail])

Name: Flo Camus
Institution: UCL
Email: [[e-mail]](mailto:[e-mail])

Dataset Overview
Three experiments were carried out to compare metabolism in stalk-eyed flies (Teleopsis dalmanni), of both sexes, that carry wildtype or meiotic drive X chromosomes: (1) the **oroboros** dataset compares mitochondrial function through high-resolution respirometry, (2) the **maven** dataset compares whole-organism metabolic rate, (3) the **diet** dataset compares dietary consumption.

We have submitted data from our three experiments:

1. High-resolution respirometry (**oroboros.csv**),
2. Whole organism metabolic rate (**maven2.csv**),
3. Diet consumption (**diet.csv**).

## Descriptions

### **1. High-Resolution Respirometry**\_Data

A full description of the measurements made using high-resolution re...,