Epigenetic regulation of transcription of naive and primed pluripotent stem cells. Mus musculus

Naive and primed pluripotent stem cells represent two different pluripotent states. Primed pluripotent stem cells following in vitro culture exhibit lower developmental potency as evidenced by failure in germline chimera assays, unlike mouse naive pluripotent stem cells. However, the molecular mechanisms underlying the lower developmental competency of primed pluripotent stem cells remain elusive. We performed ChIP-seq analysis of primed pluripotent stem cells and compared them with naive pluripotent stem cells.