Functional analysis of SSB of the hyperthermophilic archaeon Sulfolobus islandicus REY15A

Single-stranded DNA binding proteins (SSBs) have been regarded as indispensable factors in all three domains of life since they play vital roles in DNA replication. However, the exact physiological role of crenarchaeal SSBs remains ambiguous and unclear. In this study, we performed genetic, biochemical and transcriptomic studies on both the canonical SSB (SisSSB) and a non-canonical SSB (SisDPB) in the hyperthermophilic archaeon S. islandicus REY15A.