Expression data from resting and activated murine T cell as well as murine peripheral T cell lymphomas

Peripheral T-cell lymphomas (PTCLs) represent a significant unmet medical need with dismal clinical outcome.T-cell receptor (TCR) is emerging as a key driver of T lymphocytes transformation. However, the role of chronic TCR activation in lymphomagenesis and in survival of lymphoma cells is still poorly understood. Using an original mouse model, we report here that chronic TCR stimulation drives T-cell lymphomagenesis whereas TCR signaling does not contribute to PTCL survival. Transcriptome analyses of mouse PTCLs revealed a NK-like reprogramming of PTCL cells with expression of NK receptors (NKRs) and downstream signaling molecules such as Tyrobp and Syk. 15 samples. 9 mPTCLs generated after transfert of p53KO T cells into syngeneic recipient C57BL/6 CD3KO mice and 6 control T cells (3 repetitions of resting T cells and 3 repetitions of in vitro activated p53KO T cells)