B cell activation

B cell activation involves a detailed investigation of B cell responses to various stimuli, such as BCR and TLR pathways, through RNA-seq, single-cell RNA-seq, and ATAC-seq. This study reveals how immune-mediated disease (IMD)-associated genes respond to activation, identifies key transcription factors, and highlights a lupus risk variant involved in TNFSF4 regulation. Data are accessible through an interactive browser to explore gene regulation and B cell differentiation.本数据集聚焦B细胞活化研究，通过RNA测序（RNA-seq）、单细胞RNA测序（single-cell RNA-seq）及转座酶可及性测序（ATAC-seq），系统探究了B细胞对多种刺激信号（如B细胞受体（B cell receptor, BCR）通路与Toll样受体（Toll-like receptor, TLR）通路）的应答反应。本研究揭示了免疫介导疾病（immune-mediated disease, IMD）相关基因对活化过程的应答模式，鉴定出关键转录因子，并重点阐明了参与肿瘤坏死因子超家族4（TNFSF4）调控的狼疮风险变异位点。研究数据可通过交互式浏览器获取，用于探索基因调控与B细胞分化过程。

搜集汇总

背景与挑战

背景概述

该数据集利用多组学技术（包括RNA-seq、单细胞RNA-seq和ATAC-seq）深入探究B细胞对BCR和TLR等刺激的激活反应。它揭示了免疫介导疾病相关基因的响应模式，识别了关键转录因子，并发现一个与狼疮风险相关的变异参与TNFSF4调控，数据可通过交互式浏览器进行探索。