Crystal structure of an allosteric inhibitor bound to human RIPK1 kinase domain
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Crystal structure of an allosteric inhibitor bound to human RIPK1 kinase domain Descriptor: 1-[2,5-bis(chloranyl)phenyl]carbonyl-~{N}-[(4-methylphenyl)methyl]piperidine-4-carboxamide, IODIDE ION, N-[(1S)-1-(2-chloro-6-fluorophenyl)ethyl]-5-cyano-1-methyl-1H-pyrrole-2-carboxamide, ... Authors: Maskos, K, Johannsson, S, Kempf, G, Neumann, L, Cross, J.B. Deposit date: 2025-01-09 Release date: 2025-12-24 Last modified: 2026-01-28 Method: X-RAY DIFFRACTION (2.98 Å) Cite: Allosteric targeting of RIPK1: discovery of novel inhibitors via parallel virtual screening and structure-guided optimization. Rsc Med Chem, 16, 2025
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2025-01-09
