ISOTYPE SWITCHING COUNTERS HIV VIRAL ESCAPE AND ENABLES CONTINUED ANTIBODY MATURATION

NIAID Data Ecosystem2026-04-25 收录

HIV免疫逃逸

抗体亲和力成熟

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP216944 数据链接链接失效反馈

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资源简介：

Identify viral escape mutations to different antibody isotypes and the role of this on antibody evolution

创建时间：

2019-12-01

Continuous Germinal Center Invasion Contributes to the Diversity of the Immune Response

生发中心B细胞动力学

抗体亲和力成熟

Antibody responses are characterized by increasing affinity and diversity over time. Affinity maturation occurs in germinal centers by a mechanism that involves repeated cycles of somatic mutation and

NIAID Data Ecosystem40

Transcription factor T-bet in B cells controls germinal centre polarization and antibody affinity maturation in response to malaria (RNA-seq). Transcription factor T-bet in B cells controls germinal centre polarization and antibody affinity maturation in response to malaria (RNA-seq)

B细胞免疫应答

抗体亲和力成熟

Despite the key role that antibodies play in protection against malaria, the cellular processes modulating the acquisition of immunity are not fully understood. Using an infection model of severe mala

NIAID Data Ecosystem20

MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape.

HIV免疫逃逸

MHC-I肽呈递机制

The epitope was eluted from HLA-B*57:01 expressing C1R cell that were transfected with HIV-gag but not from C2R cells not expressing HIV-gag.

ImmuneData20

Appendix S1 - Immune Activation Promotes Evolutionary Conservation of T-Cell Epitopes in HIV-1

HIV免疫逃逸

动力学建模

Model variables, parameters, and systems of differential equations describing the dynamics of wild-type and T-cell (TH/CTL) escape viruses for the HIV and control models. (PDF)

Figshare2015-12-02 更新20

Summary of observed enriching mutations.

抗体亲和力成熟

抗体工程

Table of HC and LC point mutation, insertion, and deletion events observed during affinity maturation of APE777. The first column indicates the amino acid mutation, listed with Kabat numbering. The se

NIAID Data Ecosystem20

ISOTYPE SWITCHING COUNTERS HIV VIRAL ESCAPE AND ENABLES CONTINUED ANTIBODY MATURATION

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