Bioinformatic datasets for "Evolution of allostery without shape shifting: Internal dynamics drives functional diversification of a transcriptional repressor superfamily"

This dataset contains the bioinformatic files used in Antelo et al. (2026) to analyze sequence conservation and functional diversification in the ArsR/SmtB transcriptional repressor family. It includes the Sequence Similarity Network (SSN) generated as described in the manuscript, cluster-derived Multiple Sequence Alignments, specificity-determining position (SDP) and structural-position analyses, and AlphaFold 3 consensus protein structures for each cluster and for the full family. Preprint: https://www.biorxiv.org/content/10.64898/2026.05.15.721447v1