NUDT14 hydrolyses UDP-Glc to G1P and UMP

Uridine diphosphate glucose pyrophosphatase (NUDT14) is a member of the Nudix hydrolase family, a ubiquitously distributed group of nucleotide pyrophosphatases. NUDT14 hydrolyses UDP-glucose (UDP-Glc) to glucose 1-phosphate (G1P) and UMP. UDP-Glc is a sugar donor in many glycosylation reactions and a cytosolic pyrophosphatase such as NUDT14 could play a role in regulating gluconeogenesis (Yagi et al. 2003).

尿苷二磷酸葡萄糖焦磷酸酶（NUDT14）属于Nudix水解酶家族，这是一类普遍分布的核苷酸焦磷酸酶群体。NUDT14能够将UDP-葡萄糖（UDP-Glc）水解为葡萄糖-1-磷酸（G1P）和UMP。UDP-Glc作为众多糖基化反应的糖供体，而细胞质中的焦磷酸酶如NUDT14可能在调节糖异生过程中发挥重要作用（Yagi等，2003年）。