Lewis Acid Catalyzed Cascade Reaction of 3‑(2-Benzenesulfonamide)propargylic Alcohols to Spiro[indene-benzosultam]s
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https://figshare.com/articles/dataset/Lewis_Acid_Catalyzed_Cascade_Reaction_of_3_2_Benzenesulfonamide_propargylic_Alcohols_to_Spiro_indene_benzosultam_s/2215387
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资源简介：
A highly efficient and convenient
construction of the spiro[indene-benzosultam]
skeleton from propargylic alcohols has been developed. The reaction
proceeded in a Lewis acid catalyzed cascade process, including the
trapping of allene carbocation with sulfonamide, electrophilic cyclization,
and intramolecular Friedel–Crafts alkylation. In the presence
of NIS or NBS, iodo/bromo-substituted spiro[indene-benzosultam]s could
be prepared in excellent yields.
创建时间：
2015-01-16
