Lewis Acid Catalyzed Cascade Reaction of 3‑(2-Benzenesulfonamide)propargylic Alcohols to Spiro[indene-benzosultam]s
收藏NIAID Data Ecosystem2026-03-07 收录
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资源简介：
A highly efficient and convenient construction of the spiro[indene-benzosultam] skeleton from propargylic alcohols has been developed. The reaction proceeded in a Lewis acid catalyzed cascade process, including the trapping of allene carbocation with sulfonamide, electrophilic cyclization, and intramolecular Friedel–Crafts alkylation. In the presence of NIS or NBS, iodo/bromo-substituted spiro[indene-benzosultam]s could be prepared in excellent yields.
创建时间：
2015-01-16
