DNA methylation state is associated with the formation of loops and links in hematopoietic stem cells [HiC]. DNA methylation state is associated with the formation of loops and links in hematopoietic stem cells [HiC]

We present the high resolution HiC study of genome folding in primary cells, specifically hematopoietic stem and progenitor cells. We investigated the relationship of chromosomal contacts with other epigenetic marks, particularly DNA methylation and histone modifications which is known to be important for appropriate stem cell differentiation. Overall design: We used in situ Hi-C to probe relationship of chromosomal contacts and epigenetic modification.