Performance comparison between the meiosis-specific network and iMM904 in predicting sporulation-deficient genes using hypergeometric P-values.

&The Pearson correlation between in silico fluxes and biochemical values on eight pathways is calculated for each gene KO and WT. A z-score is computed to measure the difference in correlation coefficient between a KO and WT. A KO with z-score≤−2 for at least one time point is predicted to be a sporulation-deficient gene. *The optimal objective value is obtained for each gene KO and WT. A z-score is computed to measure the difference in optimal objective value between a KO and WT. A KO with z-score≤−2 for at least one time point is predicted to be a sporulation-deficient gene. #The total flux difference between a gene KO and WT is obtained from linear MOMA. A KO with flux difference≥1000 for at least one time point is predicted to be a sporulation-deficient gene.