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Remote Control of Axial Chirality: Aminocatalytic Desymmetrization of <i>N</i>‑Arylmaleimides via Vinylogous Michael Addition

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NIAID Data Ecosystem2026-03-08 收录
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Remote control of the axial chirality of N-(2-t-butylphenyl)­succinimides was realized via the vinylogous Michael addition of 3-substituted cyclohexenones to N-(2-t-butylphenyl)­maleimides. 9-Amino­(9-deoxy)epi-quinine promoted the enantioselective desymmetrization, leading to atropisomeric succinimides with two adjacent stereocenters.

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2014-07-23
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