LSD1-CoREST in complex with T105 1S2R enantiomer
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LSD1-CoREST in complex with T105 1S2R enantiomer Descriptor: 3-[(1R,2S)-2-(cyclobutylamino)cyclopropyl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide, Lysine-specific histone demethylase 1A, REST corepressor 1, ... Authors: Caroli, J, Mattevi, A. Deposit date: 2024-12-04 Release date: 2025-02-05 Last modified: 2025-08-20 Method: X-RAY DIFFRACTION (2.91 Å) Cite: Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance. Nat Commun, 16, 2025
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2024-12-04
