Replica of a Fishy Enzyme: Structure–Function Analogue of Trimethylamine-N-Oxide Reductase
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https://figshare.com/articles/dataset/Replica_of_a_Fishy_Enzyme_Structure_Function_Analogue_of_Trimethylamine_N_Oxide_Reductase/2418190
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资源简介：
Three new complexes,
[MoIVO(mnt)(SS)]2‑ (SS = dimethylethylenedicarboxylate
(DMED), toluenedithiolate (tdt),
benzenedithiolate (bdt); mnt = maleonitriledithiolate), each possessing
two different dithiolene ligands, are synthesized as model of trimethylamine-N-oxide
reductase. The asymmetric dithiolene ligands present in these complexes
simulate the two different (P and Q) pterin coordinations in the family
of DMSO reductase. These complexes reduce trimethylamine-N-oxide ((CH3)3N+–O– or
TMANO), the biological substrate of trimethylamine-N-oxide reductase,
to trimethylamine ((CH3)3N), responsible for
the fishy smell of dead aquatic animals. The reaction kinetics of
trimethylamine-N-oxide reduction by these complexes follow the Michaelis–Menten
saturation kinetics. These experimental findings have been rationalized
by DFT, TD-DFT level of calculations.
创建时间：
2016-02-19
