The rs10830963 SNP of the MTNR1B gene in the Czech cohort

Disruptions in biorhythms contribute to the development of type 2 diabetes mellitus. The <i>MTNR1B</i> gene encodes a receptor for melatonin, a hormone regulating biorhythms, and genetic studies suggest that variability in the <i>MTNR1B</i> gene is related to the development of T2DM, with the single nucleotide polymorphism rs10830963 showing the strongest association. Our aim was to compare the distribution of the genetic variant rs10830963 between persons differing in glucose tolerance (N=1206).