Differentially Expressed Genes upon Knockdown of ZRANB1 or EZH2 in LM2 Cells
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE104910
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EZH2, the catalytic component of the Polycomb repressive complex 2 (PRC2), silences gene transcription by methylating histone H3 at lysine 27. Recently we identified ZRANB1 as the EZH2 deubiquitinase. ZRANB1 binds, deubiquitinates, and stabilizes EZH2. To determine whether ZRANB1 is a functional regulator of EZH2, we performed RNA-Seq analysis to compare the effect of ZRANB1 knockdown or EZH2 knockdown on global gene expression. mRNA profiles of control, ZRANB1 knockown, or EZH2 knockdown LM2 cells were generated from triplicate samples using RNA-Seq
创建时间：
2019-05-15
