Sufu and Spop cooperate to suppress SHH medulloblastoma tumorigenesis via regulation of Gli2 protein stability [ChIP-seq]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE112702
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GLI2 overexpression is a hallmark in SHH subgroup of medulloblastoma (SHH MB). Here we identify the targetome of Gli2 in two mouse models of SHH MB: SmoM2 overexpression and Sufu;Spop double knockout MB. Examination of Gli2-bound DNA and H3K27ac- and H3K36me3-modified DNA in P13 Sufu;Spop double knockout and SmoM2 overexpression medulloblastoma in mice
创建时间：
2019-03-21
