File S1 - Genetic Analysis of Loop Sequences in the Let-7 Gene Family Reveal a Relationship between Loop Evolution and Multiple IsomiRs

Figure S1. Examples of neighbor-joining tree of the loop and pre-miRNA sequences in the let-7 gene family. Figure S2. Sequence logo of loop sequences and miRNA sequences. (A) Sequence logo of loop sequences from single let-7 genes and (B) sequence logo of relevant mature miRNAs (including miR-#-5p and miR-#-3p). Table S1. Loop sequence length distribution from Figure 2B. Table S2. Nucleotide composition and frequency. Table S3. 95% confidence interval (CI) and difference between length distributions of let-7 and related clustered miRNAs. Table S4. Effect on minimum free energy (MFE) when changing loop sequence lengths in hsa-let-7a-1. (DOC)