PANDIT

Efforts to obtain renewed funding after 2008 were unfortunately not successful. PANDIT has therefore been frozen since November 2008, and its data are not updated since September 2005 when version 17.0 was released (corresponding to Pfam 17.0). The existing data and website remain available from these pages, and should remain stable and, we hope, useful. PANDIT is a collection of multiple sequence alignments and phylogenetic trees. It contains corresponding amino acid and nucleotide sequence alignments, with trees inferred from each alignment. PANDIT is based on the Pfam database (Protein families database of alignments and HMMs), and includes the seed amino acid alignments of most families in the Pfam-A database. DNA sequences for as many members of each family as possible are extracted from the EMBL Nucleotide Sequence Database and aligned according to the amino acid alignment. PANDIT also contains a further copy of the amino acid alignments, restricted to the sequences for which DNA sequences were found.

自2008年寻求资金续期以来，遗憾的是并未取得成功。因此，PANDIT项目自2008年11月起已进入冻结状态，其数据自2005年9月发布17.0版本（对应于Pfam 17.0）以来未曾更新。现有的数据与网站内容可通过相关页面获取，我们期望这些内容将持续稳定，并保持其实用性。PANDIT是一个多序列比对与系统发育树的集合。它包含了与每个比对相对应的氨基酸和核酸序列比对，并从每个比对中推断出系统发育树。PANDIT基于Pfam数据库（比对与隐马尔可夫模型蛋白质家族数据库），并包含了Pfam-A数据库中大多数家族的种子氨基酸比对。尽可能从EMBL核酸序列数据库中提取每个家族成员的DNA序列，并根据氨基酸比对进行对齐。PANDIT还包含了一份额外的氨基酸比对副本，该副本仅限于已找到DNA序列的序列。