Whole Exome Sequencing (WES) of Dnmt3a R878H Leukemic Mice

DNMT3A is frequently mutated in acute myeloid leukemia (AML). To recapitulate the features of human AML with hotspot DNMT3A R882H mutation, we generated Dnmt3a R878H conditional knock-in mice, which developed full-blown AML. To determine whether cooperating mutations occurred in Dnmt3aR878H/WT leukemic mice, we performed whole-exome sequencing (WES) in BM samples and paired normal tail specimens from three diseased animals. Exome sequencing data suggest that Dnmt3a mutation is sufficient to drive AML.In this dataset, we provided WES data in Dnmt3a R878H/WT mice.