Stable silencing of the inactive X chromosome (Xi) in female mammals is crucial for the development of embryos and their postnatal health. SmcHD1 is essential for stable silencing of the Xi, and its f

NIAID Data Ecosystem50

H3K27me3 and CTCF ChIP-seq in reciprocal wild-type and SmcHD1 MommeD1mut MEF cell lines. H3K27me3 and CTCF ChIP-seq in reciprocal wild-type and SmcHD1 MommeD1mut MEF cell lines

表观遗传调控

X染色体失活

In this study we investigate the role of the non-canonical SMC family protein, SmcHD1in the X inactivation. Overall design: Set of allele-specific ChIP-seq experiments on female clonal inter-specific

NIAID Data Ecosystem30

8p H3K27me3 Part 2

表观遗传

X染色体失活

Green is RNA FISH using a probe against XIST RNA. Red is an anti-H3K27me3 antibody. Blue is DAPI. These images were used to calculate data shown in Table 2.

Figshare2016-01-20 更新80

XIST directly regulates X-linked and autosomal genes in naÃ¯ve human pluripotent cells [scRNA-seq]

X染色体失活

单细胞转录组学

X-chromosome inactivation (XCI) serves as a paradigm for RNA-mediated regulation of gene expression, wherein the long non-coding RNA XIST spreads across the X-chromosome in cis to mediate chromosome-w

NIAID Data Ecosystem40

Spreading of X-chromosome inactivation via a hierarchy of defined Polycomb stations

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