The Role of SMAD4 in Breast Cancer Endocrine Resistance [RNA-seq]

To investigate transcriptomic changes, we performed two rounds of RNA-seq. In the first round, parental or SMAD4 knockout MCF7 cells were treated with DMSO or OHT for 24 hours were used. In the second round, parental MCF7 cells or SMAD4 knockout MCF7 cells treated with DMSO or LAPA + OHT for 24 hours were used.