Palladium-Catalyzed Intramolecular Heck/Aminocarbonylation of Alkene-Tethered Iodobenzenes with Nitro Compounds: Synthesis of Carbamoyl-Substituted Benzoheterocycles

A palladium-catalyzed intramolecular Heck/aminocarbonylation
of
alkene-tethered iodobenzenes with nitro compounds has been developed
for the synthesis of carbamoyl-substituted benzoheterocycles. Using
Mo­(CO)6 as a solid CO source, no external reductant or
additives were needed in this procedure. Both nitroarenes and nitroalkanes
were well tolerated. A range of carbamoyl-substituted dihydrobenzofurans
and indolines were prepared in moderate to high yields.