CPDB
收藏资源简介:
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.
致癌性潜力数据库(Carcinogenic Potency Database, CPDB)是一款独特且被广泛应用的国际性资源,收录了针对1547种化学物质开展的6540项慢性长期动物癌症实验结果。该数据库可便捷获取相关癌症生物测定文献,并针对两类实验数据提供定性与定量分析:一类是截至2001年的公开学术文献中、近50年间发表的正负向实验结果,另一类是美国国家癌症研究所(National Cancer Institute, NCI)与美国国家毒理学计划(National Toxicology Program, NTP)截至2004年发布的实验结果。CPDB对异质性极强的癌症生物测定文献进行了标准化整合——此类文献在实验方案、组织病理学检查规范、术语命名体系,乃至论文作者披露的信息维度上均存在显著差异。数据库中收录了针对大鼠、小鼠、仓鼠、犬类及非人灵长类动物开展的实验结果。



