Expression data from mouse skeletal muscle

Evidence suggests that diabetes mellitus is a promoting factor of sarcopenia; mechanism of how diabetes mellitus accelerates the development of sarcopenia is not known. We have recently established a model of diabetes-induced skeletal muscle mass loss in mice by using streptozotocin. We used microarrays to detail the global programme of gene expression underlying skeletal muscle atrophy in STZ treated mice and identified up-regulated or down-regulated genes during this process. Gastrocnemius muscle were selected at 3 weeks after STZ treatment of wild type or skeletal muscle specific KLF15 knockout mice for RNA extraction and hybridization on Affymetrix microarrays.