A temporal shift in regulatory networks and pathways in the bovine small intestine during Cooperia oncophora infection

Cooperia oncophora is an important parasitic nematode of ruminants with a worldwide distribution. Twenty Holstein nematode-naive bull calves were experimentally infected with approximately 100,000 L3 stage infective larvae for 7, 14, 28, 42 days, respectively. The experiment was conducted in order to identify putative recognition and inflammatory pathways in the host-parasite relationship. Gene expression profiles in the small intestine were compared using a high-density bovine 60mer oligo microarray. A total of 310 sequences were differentially expressed during the course of infection (P

Cooperia oncophora（瘤胃结节线虫）是全球范围内分布的重要反刍动物寄生虫。本研究选取了20头荷斯坦牛未感染结节线虫的公犊，分别用约10万条L3期感染性幼虫进行实验感染，持续时间为7天、14天、28天和42天。本实验旨在识别宿主-寄生虫关系中的潜在识别和炎症通路。通过高密度牛60mer寡核苷酸微阵列比较了小肠中的基因表达谱。在感染过程中，共有310个序列表现出差异表达（P