Protective efficacy of IPT against clinical malaria, high parasite density malaria and anaemia.

Protective efficacy of IPTi by week since treatment for all IPT doses combined. Protective efficacy is shown against clinical malaria (history of fever or temperature ≥37.5°C plus malaria parasites detected on a blood smear), high parasite density malaria (clinical malaria with parasite density ≥5000 parasites/µl) and anaemia (packed cell volume <24%). All episodes that occurred before two years of age were included in the analyses. No long term protection was observed; for brevity estimates are presented up to twenty weeks following treatment. Fewer episodes of anaemia made it necessary to stratify follow-up every two weeks for this endpoint.