Perioperative Testosterone Supplementation Improves Short-Term Outcomes of Anterior Urethroplasty in Hypogonadal Models: Insights from a Preclinical Rabbit Study

To investigate whether perioperative androgen supplementation could improve surgical outcomes of anterior urethroplasty, particularly in hypogonadal patients, we evaluated the effects and mechanisms of systemic androgen supplementation at different doses in a castrated New Zealand rabbit model of bulbar urethroplasty. Overall design: Fifteen castrated and five non-castrated adult male New Zealand rabbits were randomized into four groups: non-castrated control (NC), castrated control (0 mg/kg), physiological dose (2.5 mg/kg), and supraphysiological dose (5 mg/kg) of testosterone propionate.